• Research Questions

  • What is the connection between adult hippocampal neurogenesis and behavior?

  • How adult hippocampal neurogenesis is affected in neurobehavioral disorders?

  • What are the molecular ques regulating adult neurogenesis, self-renewal, differentiation and maturation?

  • How the immune system, and in particularly T-cells and macrophages affect neurogenesis and behavior?

  • How can mesenchymal stem cell (MSC) transplantation either locally or systemically affect adult hippocampal neurogenesis? What are the molecular and cellular mechanisms that are involved?

  • Can MSC transplantation be of therapeutic benefits for neurobehavioral disorders such as autism  spectrum disorders and schizophrenia?

  • Do neurobehavioral disorders share common pathophysiological mechanisms (epigenetics) with aging? 

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• Methodologies used

  • Immunohistochemistry

  • In vivo real-time Imaging

  • Stem transplantation

  • Behavioral Neuroscience

  • Gene expression

  • FACS

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• Keywords

  • Adult hippocampal neurogenesis, stem cells, learning and memory, T-cells, macrophages, neurobehavioral disorders, ASD, Schizophrenia