• Research Questions

  • What is the role of  microRNAs in  tau gene regulation?

  • What is mechanism of action of MicroRNAs in tau expression and function?

  • Development of diagnostic tools for identification of Alzheimer disease and taupaties by using MicroRNAs profiles.

​

• Methodologies used

  • In vito  and  in vivo analysis

  • Molecular biology and  Biochemical methods

  • High-throughput methods: transcriptomics

  • Bioinformatic  analysis to identification of mircoRNA profiles

  • Validation  analsysis using qRT-PCR (normal versus pateints)

​

• Keywords

  • Alzheimer disease, Tau, microRNAs, neurodegenerative diseases, mRNA